Ethylenediamine Salt Enhances the Solubility and Dissolution of Flurbiprofen.
ChemistryOpen
; 13(6): e202300262, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38214691
ABSTRACT
Drugs that are poorly soluble in water are difficult to absorb orally, resulting in low bioavailability. Flurbiprofen (FLU) is an arylpropionic acid nonsteroidal anti-inflammatory drug belonging to BCS class II, with low water solubility. In this study, a novel flurbiprofen-ethylenediamine salt (FLU-EDA) was successfully prepared via solvent crystallization. Its crystal structure was determined via single-crystal X-ray diffraction (SXRD). Further, the physicochemical properties of FLU-EDA salt were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FT-IR). The solubility and intrinsic dissolution rate (IDR) of FLU-EDA salt in water were investigated. The results showed that compared with FLU, the solubility and IDR of FLU-EDA salt increased by 57-fold and 32-fold, respectively. This indicates that FLU-EDA salt can significantly enhance the solubility and dissolution rate of flurbiprofen in water. This study provides basic data and theory for the development of new formulations of flurbiprofen.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Solubilidade
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Flurbiprofeno
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Etilenodiaminas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article