Protocol for producing phosphoramidate using phosphorus fluoride exchange click chemistry.
STAR Protoc
; 5(1): 102824, 2024 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-38217854
ABSTRACT
Phosphorus fluoride exchange (PFEx) is a catalytic click reaction that involves exchanging high oxidation state P-F bonds with alcohol and amine nucleophiles, reliably yielding P-O- and P-N-linked compounds. Here, we describe steps for preparing a phosphoramidic difluoride and performing two sequential PFEx reactions to yield a phosphoramidate through careful catalyst selection. We then detail procedures for handling and quenching potentially toxic P-F-containing compounds to ensure user safety when conducting PFEx reactions. For complete details on the use and execution of this protocol, please refer to Sun et al.1.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Química Click
/
Fluoretos
/
Amidas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article