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Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potential.
Jinliang, Duan; Fang, Bai; Xiaofeng, Zhu; Xiaoshun, He; Anbin, Hu.
Afiliação
  • Jinliang D; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial I
  • Fang B; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial I
  • Xiaofeng Z; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial I
  • Xiaoshun H; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial I
  • Anbin H; Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial I
Stem Cell Res ; 75: 103302, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38217994
ABSTRACT
CCL22 is a macrophage-derived immunosuppressive chemokine that recruits regulatory T cells through the CCL22CCR4 axis, playing an important role in homeostatic and inflammatory responses. A CCL22-overexpressing human induced pluripotent stem cell line (CNNDi001-A-2) was generated by lentiviral transduction to further study the function of CCL22. The cell line was confirmed to have normal proliferation and pluripotency and could be further differentiated into islet cells for cell replacement therapy in diabetes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Células-Tronco Pluripotentes Induzidas Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Células-Tronco Pluripotentes Induzidas Idioma: En Ano de publicação: 2024 Tipo de documento: Article