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Natural compound Sanggenon C inhibits porcine reproductive and respiratory syndrome virus replication in piglets.
Liu, Xiao; Meng, Yinan; He, Jianyu; Jiang, Xuelian; Zhang, Shuangquan; Wang, Dan; Zhu, Yanan; Zheng, Zifang; Fan, Yunpeng; Yin, Yupeng; Xiao, Shuqi.
Afiliação
  • Liu X; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China; State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou
  • Meng Y; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China.
  • He J; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China.
  • Jiang X; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China.
  • Zhang S; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China.
  • Wang D; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China.
  • Zhu Y; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China.
  • Zheng Z; State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou 730046, Gansu, China.
  • Fan Y; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China.
  • Yin Y; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address: yupengyin@yeah.net.
  • Xiao S; State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou 730046, Gansu, China. Electronic address: shqxiaojd@126.com.
Vet Microbiol ; 290: 109991, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38228078
ABSTRACT
Porcine reproductive and respiratory syndrome virus is one of the main pathogens threatening the global pig industry, and there is still a lack of effective therapeutic drugs. Sanggenon C is a flavanone Diels-Alder adduct compound extracted from the root bark of the mulberry genus, which has blood pressure-reducing, anti-atherosclerotic, anti-oxidative, and anti-inflammatory effects. In our previous study, Sanggenon C was confirmed to significantly inhibit PRRSV replication in vitro. However, its antiviral potential to inhibit PRRSV infection in vivo has not been evaluated in piglets. Here, the antiviral effect of Sanggenon C was evaluated in PRRSV-challenged piglets based on assessments of rectal temperature, viral load, pathological changes of lung tissue and secretion of inflammatory cytokines. The results showed that Sanggenon C treatment relieved the clinical symptoms, reduced the viral loads in the lungs and bloods, alleviated the pathological damage of lung tissue, decreased the secretion of inflammatory cytokines, and shorten the excretion time of virus from the oral and nasal secretions and feces of piglets after PRRSV infection. The results indicated that Sanggenon C is a promising anti-PRRSV drug, which provides a new strategy for the prevention and control of PRRS in clinical practice.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças dos Suínos / Benzofuranos / Cromonas / Vírus da Síndrome Respiratória e Reprodutiva Suína / Síndrome Respiratória e Reprodutiva Suína Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças dos Suínos / Benzofuranos / Cromonas / Vírus da Síndrome Respiratória e Reprodutiva Suína / Síndrome Respiratória e Reprodutiva Suína Idioma: En Ano de publicação: 2024 Tipo de documento: Article