Association between endothelial biomarkers and lipid and glycemic levels: a cross-sectional study with diabetic patients.
Biomark Med
; 17(22): 935-946, 2023 11.
Article
em En
| MEDLINE
| ID: mdl-38230971
ABSTRACT
Background:
Biomarkers can help understand the impact of achieving therapeutic goals in developing vascular diseases in diabetics.Aim:
To assess the association between lipid and glycemic profiles and endothelial biomarkers in diabetics.Methods:
Cross-sectional study that evaluated lipid and glycemic levels and biomarkers (VCAM-1, Sdc-1, FGF-23 and KIM-1 in diabetics.Results:
Higher VCAM-1 levels were associated with higher low-density lipoprotein cholesterol and non-high-density lipoprotein (HDL) cholesterol levels (in the group with inadequate glycohemoglobin A1c [HbA1c] levels), with higher glycemic levels (in the group with inadequate HDL cholesterol levels) and with lower HDL cholesterol levels (both groups). VCAM-1 was independently associated with not achieving adequate HbA1c levels.Conclusion:
In uncontrolled diabetics, VCAM-1 was independently associated with having inadequate HbA1c levels, suggesting they may already have endothelial damage.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article