Differences between young and elderly polypoidal choroidal vasculopathy patients with and without pachychoroid phenotypes.
Graefes Arch Clin Exp Ophthalmol
; 262(6): 1765-1776, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38231247
ABSTRACT
PURPOSE:
To investigate the distinct characteristics between young and elderly polypoidal choroidal vasculopathy (PCV) patients based on the pachy- or non-pachychoroid phenotypes.METHODS:
PCV patients treated with intravitreal injections of Conbercept based on the 3 + PRN regimen from 27 centers of China PCV Research Alliance were included. Patients were categorized into the young and the elderly aged group based on the cut-off point determined using the Youden method according to the pachychoroid phenotypes. The characteristics of past medical history, lifestyle factors, fundus manifestations, and treatment response between the subgroups were analyzed.RESULTS:
Three hundred eight eligible patients were included. Multivariate logistic regression showed a significant association between age and PCV subtype classification (OR = 0.921, P = 0.002). A cutoff age of 64.5 effectively distinguished between pachychoroid PCV and non-pachychoroid PCV (P < 0.001). Elderly PCV patients had a higher incidence of hypertension history (P = 0.044) but a lower incidence of diabetes history (P = 0.027). In terms of lifestyle, smoking history (P = 0.015) and staying up late (P = 0.004) were more significant in the young group of PCV patients. For clinical characteristics, the proportion of hemorrhagic PCV in the young group was significantly higher (P = 0.038), with a higher proportion of sharp-peaked PED (P = 0.049), thicker choroid (P < 0.001) but a lower portion of double-layer sign (P = 0.023) in OCT. Both groups showed significant anatomical changes compared to baseline in each follow-up period (P < 0.05), with the young group having a higher proportion of good anatomical response after the first injection (P = 0.009).CONCLUSION:
PCV patients stratified by subtype exhibit distinct characteristics between the young and elderly groups.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenótipo
/
Pólipos
/
Angiofluoresceinografia
/
Acuidade Visual
/
Corioide
/
Tomografia de Coerência Óptica
/
Injeções Intravítreas
/
Fundo de Olho
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article