Can C-reactive protein be used as a surrogate marker of IL-6 in a broad array of clinical entities?
Biomark Med
; 17(24): 1001-1010, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-38235562
ABSTRACT
Background:
C-reactive protein (CRP) is commonly performed, whereas cytokine testing is limited to research.Aims:
To determine CRP correlation to cytokines IL-6, IL-1ß and TNF-α.Results:
Consecutive samples (n = 307) were collected over 24 h. Ninety-six patients (31%) had acute infections, and 23 patients (7.5%) had autoimmune or inflammatory disease presentations. A strong correlation between CRP and two IL-6 assays (r = 0.74 and r = 0.71; p < 0.001) was present. CRP did not correlate with IL-1ß and TNF-α across the data set. Bacterial infection had a significantly higher CRP and IL-6 (p < 0.001), while only CRP was elevated in inflammatory and autoimmune diseases (p < 0.001).Discussion:
CRP may be used as a surrogate marker of IL-6 levels in the routine diagnostic laboratories.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Interleucina-6
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article