Diurnal Variation of Brain Activity in the Human Suprachiasmatic Nucleus.
J Neurosci
; 44(8)2024 Feb 21.
Article
em En
| MEDLINE
| ID: mdl-38238074
ABSTRACT
The suprachiasmatic nucleus (SCN) is the central clock for circadian rhythms. Animal studies have revealed daily rhythms in the neuronal activity in the SCN. However, the circadian activity of the human SCN has remained elusive. In this study, to reveal the diurnal variation of the SCN activity in humans, we localized the SCN by employing an areal boundary mapping technique to resting-state functional images and investigated the SCN activity using perfusion imaging. In the first experiment (n = 27, including both sexes), we scanned each participant four times a day, every 6â
h. Higher activity was observed at noon, while lower activity was recorded in the early morning. In the second experiment (n = 20, including both sexes), the SCN activity was measured every 30â
min for 6â
h from midnight to dawn. The results showed that the SCN activity gradually decreased and was not associated with the electroencephalography. Furthermore, the SCN activity was compatible with the rodent SCN activity after switching off the lights. These results suggest that the diurnal variation of the human SCN follows the zeitgeber cycles of nocturnal and diurnal mammals and is modulated by physical lights rather than the local time.
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Base de dados:
MEDLINE
Assunto principal:
Núcleo Supraquiasmático
/
Ritmo Circadiano
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article