Metagenomic analysis of Mesolithic chewed pitch reveals poor oral health among stone age individuals.
Sci Rep
; 13(1): 22125, 2024 01 18.
Article
em En
| MEDLINE
| ID: mdl-38238372
ABSTRACT
Prehistoric chewed pitch has proven to be a useful source of ancient DNA, both from humans and their microbiomes. Here we present the metagenomic analysis of three pieces of chewed pitch from Huseby Klev, Sweden, that were dated to 9,890-9,540 before present. The metagenomic profile exposes a Mesolithic oral microbiome that includes opportunistic oral pathogens. We compared the data with healthy and dysbiotic microbiome datasets and we identified increased abundance of periodontitis-associated microbes. In addition, trained machine learning models predicted dysbiosis with 70-80% probability. Moreover, we identified DNA sequences from eukaryotic species such as red fox, hazelnut, red deer and apple. Our results indicate a case of poor oral health during the Scandinavian Mesolithic, and show that pitch pieces have the potential to provide information on material use, diet and oral health.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Periodontite
/
Microbiota
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article