Regio- and Enantioselective Construction of Tetrazole Hemiaminal Esters and Related Prodrugs via Biocatalytic Dynamic Kinetic Resolution.
J Org Chem
; 89(3): 1465-1472, 2024 02 02.
Article
em En
| MEDLINE
| ID: mdl-38251869
ABSTRACT
Enzyme-catalyzed dynamic kinetic resolution was applied to the one-pot regio- and enantioselective synthesis of 2,5-disubstituted tetrazole hemiaminal esters, among which 72% of the products were obtained in excellent enantiopurities (99% ees). Tunable stereoselectivity was achieved by using different types of enzymes during the synthesis of a key intermediate for a clinic drug candidate. Successful preparation of tetrazole ester prodrugs and high catalyst recyclability further demonstrated the potential practical application of this protocol.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tetrazóis
/
Ésteres
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article