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Palladium-catalyzed ring-opening [5+2] annulation of vinylethylene carbonates (VECs) and C5-substituted Meldrum's acids: rapid synthesis of 7-membered lactones.
Li, Fei; Chen, Xin; Huang, Ben-Qing; Xu, Hua-Dong; Zhu, Chi-Fan; Shen, Mei-Hua.
Afiliação
  • Li F; School of Pharmacy, Changzhou University, Changzhou, Jiangsu Province 213164, China. chifanzhu@cczu.edu.cn.
  • Chen X; School of Pharmacy, Changzhou University, Changzhou, Jiangsu Province 213164, China. chifanzhu@cczu.edu.cn.
  • Huang BQ; School of Pharmacy, Changzhou University, Changzhou, Jiangsu Province 213164, China. chifanzhu@cczu.edu.cn.
  • Xu HD; School of Pharmacy, Changzhou University, Changzhou, Jiangsu Province 213164, China. chifanzhu@cczu.edu.cn.
  • Zhu CF; School of Pharmacy, Changzhou University, Changzhou, Jiangsu Province 213164, China. chifanzhu@cczu.edu.cn.
  • Shen MH; School of Pharmacy, Changzhou University, Changzhou, Jiangsu Province 213164, China. chifanzhu@cczu.edu.cn.
Chem Commun (Camb) ; 60(13): 1774-1777, 2024 Feb 08.
Article em En | MEDLINE | ID: mdl-38252322
ABSTRACT
A novel approach for the synthesis of unsaturated 7-membered lactones by Pd-catalyzed [5+2] dipolar cycloaddition of vinylethylene carbonates (VECs) and C5-substituted Meldrum's acid derivatives has been developed. Various Meldrum's acid derivatives worked well in this reaction under mild reaction conditions. A variety of 7-membered lactones can be accessed in a facile manner in moderate to good yields by employing easily prepared Meldrum's acid derivatives.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article