IκB kinase thwarts aggregation: Phosphorylating TDP-43 for degradation.
J Cell Biol
; 223(2)2024 02 05.
Article
em En
| MEDLINE
| ID: mdl-38252412
ABSTRACT
TDP-43 aggregation is a hallmark of neurodegeneration. In this issue, Iguchi et al. (https//doi.org/10.1083/jcb.202302048) report that IκB kinase (IKK), an important mediator of inflammation, phosphorylates cytoplasmic TDP-43 to promote proteasomal degradation, revealing an unexpected link between inflammation and TDP-43 homeostasis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complexo de Endopeptidases do Proteassoma
/
Proteínas de Ligação a DNA
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Quinase I-kappa B
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article