Risk of metabolic syndrome in patients with chronic hepatitis C.
Tunis Med
; 101(3): 362-366, 2023 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-38263917
ABSTRACT
INTRODUCTION:
Chronic hepatitis C is associated with several metabolic abnormalities including diabetes and insulin resistance. Metabolic syndrome, a major cardiovascular risk factor, may represent an additional risk of morbidity and mortality in patients with viral hepatitis C.AIM:
To assess the risk of metabolic syndrome in patients with chronic hepatitis C and its impact on liver fibrosis.METHODS:
Retrospective cohort study, including a group of exposed patients with untreated chronic hepatitis C and a group of unexposed patients with negative hepatitis C serology. We compared the prevalence of metabolic syndrome between the two groups and evaluated the association between metabolic syndrome and advanced fibrosis in the exposed patients.RESULTS:
Forty exposed and 40 unexposed were included. The two groups were matched for age, sex and anthropometric data. Fibrosis was significant in 67.5% of the exposed group. The exposed group had a significantly higher prevalence of metabolic syndrome and insulin resistance compared to the unexposed group (37.5% VS 15%; p=0.02 VS 67.5% , 37.5%; p=0.02 VS 67.5%, 37.5%; p=0.007, respectively). The relative risk of metabolic syndrome in the exposed group was 2.5. Metabolic syndrome was not associated with significant fibrosis (p=0.7).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anormalidades Múltiplas
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Resistência à Insulina
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Hepatite C
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Hepatite C Crônica
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Síndrome Metabólica
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article