The inhibition of several components of terminal complement pathway results in C3 binding to PNH red blood cells.

ABSTRACT

C3 binding on PNH red blood cells after in vitro complement activation in normal and terminal complement depleted (∆5, ∆6, ∆9) sera C3 binding, and the subsequent extravascular hemolysis, happens anytime there is a block of a component of the terminal complement pathway.