JAK/STAT in leukemia: a clinical update.
Mol Cancer
; 23(1): 25, 2024 01 26.
Article
em En
| MEDLINE
| ID: mdl-38273387
ABSTRACT
Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs). The aim of this review is to summarize the latest progress in our understanding of the involvement of the JAK/STAT signaling pathway in the development of leukemia. We also attempt to provide insights into the current use of JAK/STAT inhibitors in leukemia therapy and explore pertinent clinical trials in this field.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia
/
Transtornos Mieloproliferativos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article