Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells.
Adv Biol (Weinh)
; 8(4): e2300547, 2024 04.
Article
em En
| MEDLINE
| ID: mdl-38282178
ABSTRACT
Access to therapeutic strategies that counter cellular stress induced by reactive oxygen species (ROS) is an important, long-standing challenge. Here, the assembly of antioxidant artificial cells is based on alginate hydrogels equipped with non-native catalysts, namely platinum nanoparticles and an EUK compound. These artificial cells are able to preserve the viability and lower the intracellular ROS levels of challenged hepatic cells by removing peroxides from the extracellular environment. Conceptually, this strategy illustrates the potential use of artificial cells with a synthetic catalyst toward long-term support of hepatic cells and potentially other mammalian cells.
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Base de dados:
MEDLINE
Assunto principal:
Nanopartículas Metálicas
/
Microgéis
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article