Molecular features of luminal breast cancer defined through spatial and single-cell transcriptomics.

Yoshitake, Ryohei; Mori, Hitomi; Ha, Desiree; Wu, Xiwei; Wang, Jinhui; Wang, Xiaoqiang; Saeki, Kohei; Chang, Gregory; Shim, Hyun Jeong; Chan, Yin; Chen, Shiuan

Yoshitake, Ryohei; Mori, Hitomi; Ha, Desiree; Wu, Xiwei; Wang, Jinhui; Wang, Xiaoqiang; Saeki, Kohei; Chang, Gregory; Shim, Hyun Jeong; Chan, Yin; Chen, Shiuan.

Afiliação

Yoshitake R; Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.
Mori H; Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.
Ha D; Department of Surgery and Oncology, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
Wu X; Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.
Wang J; Integrative Genomics Core, Beckman Research Institute of City of Hope, Monrovia, California, USA.
Wang X; Integrative Genomics Core, Beckman Research Institute of City of Hope, Monrovia, California, USA.
Saeki K; Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.
Chang G; Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.
Shim HJ; Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Ehime, Japan.
Chan Y; Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.
Chen S; Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.

Clin Transl Med ; 14(1): e1548, 2024 01.

Article em En | MEDLINE | ID: mdl-38282415

Assuntos

Neoplasias da Mama; Humanos; Feminino; Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Antígeno Ki-67/genética; Receptores de Estrogênio/genética; Perfilação da Expressão Gênica; Estrogênios; Inflamação; Hipóxia

Palavras-chave

breast cancer; intratumour heterogeneity; oestrogen receptor; single-cell RNA-sequencing; spatial transcriptomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Idioma: En Ano de publicação: 2024 Tipo de documento: Article