Poor self-rated health is associated with faster cognitive decline and greater small vessel disease in older adults with type 2 diabetes.
Diabetes Metab Res Rev
; 40(1): e3761, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38287720
ABSTRACT
OBJECTIVE:
Self-rated health (SRH) is a predictor for poor health outcomes and cognition. Older adults with type 2 diabetes mellitus (T2D) have multi-morbidity and greater cognitive impairment. In the present study we investigated the association of SRH with cognitive decline and brain pathology in older adults with T2D.METHODS:
Participants (n = 1122) were from the Israel Diabetes and Cognitive Decline study, and SRH was categorised as low (n = 202), moderate (n = 400) or high (n = 520). Cognition was measured by four cognitive domains episodic memory, executive functions, language, and attention/working memory. Global cognition was the average of the cognitive domains. Statistical models adjusted for sociodemographic, cardiovascular, and clinical variables. In a randomly selected subsample (n = 230) that had magnetic resonance imaging, we examined relationships between baseline SRH and brain characteristics (white matter hyperintensities [WMHs], hippocampal, and total grey matter [GM] volumes).RESULTS:
Low SRH was associated with a decline in executive functions, which accelerated over time when compared to high SRH (est = -0.0036; p = <0.001). Compared to high SRH, low SRH was associated with a faster decline in global cognition (est = -0.0024; p = 0.009). Low SRH at baseline was associated with higher volumes of WMHs (est = 9.8420; p < 0.0008). SRH was not associated with other cognitive domains, or with hippocampal and total GM.CONCLUSIONS:
Low SRH is associated with cognitive decline in T2D older adults and may serve as a risk assessment. WMHs may represent an underlying mechanism.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças Vasculares
/
Diabetes Mellitus Tipo 2
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Disfunção Cognitiva
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article