Elevated S100B urine levels predict seizures in infants complicated by perinatal asphyxia and undergoing therapeutic hypothermia.
Clin Chem Lab Med
; 62(6): 1109-1117, 2024 May 27.
Article
em En
| MEDLINE
| ID: mdl-38290722
ABSTRACT
OBJECTIVES:
Seizures (SZ) are one of the main complications occurring in infants undergoing therapeutic hypothermia (TH) due to perinatal asphyxia (PA) and hypoxic ischemic encephalopathy (HIE). Phenobarbital (PB) is the first-line therapeutic strategy, although data on its potential side-effects need elucidation. We investigated whether i) PB administration in PA-HIE TH-treated infants affects S100B urine levels, and ii) S100B could be a reliable early predictor of SZ.METHODS:
We performed a prospective case-control study in 88 PA-HIE TH infants, complicated (n=44) or not (n=44) by SZ requiring PB treatment. S100B urine levels were measured at 11 predetermined monitoring time-points from first void up to 96-h from birth. Standard-of-care monitoring parameters were also recorded.RESULTS:
S100B significantly increased in the first 24-h independently from HIE severity in the cases who later developed SZ and requested PB treatment. ROC curve analysis showed that S100B, as SZ predictor, at a cut-off of 2.78⯵g/L achieved a sensitivity/specificity of 63 and 84â¯%, positive/negative predictive values of 83 and 64â¯%.CONCLUSIONS:
The present results offer additional support to the usefulness of S100B as a trustable diagnostic tool in the clinical daily monitoring of therapeutic and pharmacological procedures in infants complicated by PA-HIE.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Asfixia Neonatal
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Convulsões
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Subunidade beta da Proteína Ligante de Cálcio S100
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Hipotermia Induzida
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article