Synthesis of the C13-C27 Fragment of Madeirolide A Using Visible-Light-Promoted Radical Cyclization.
Org Lett
; 26(5): 1067-1072, 2024 Feb 09.
Article
em En
| MEDLINE
| ID: mdl-38293710
ABSTRACT
The convergent synthesis of a fully elaborated C13-C27 fragment of madeirolide A has been achieved. The key features of the synthesis include the stereocontrolled construction of both the THF and THP rings via visible-light-induced iridium-catalyzed radical cyclization and the late-stage union of the two oxacyclic subunits through nickel-catalyzed decarboxylative cross-coupling.
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MEDLINE
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En
Ano de publicação:
2024
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Article