Recurrent Cushing's Disease Caused by a TPIT-Lineage Densely Granulated Corticotroph Pituitary Neuroendocrine Tumor: A Case Report.
Neuro Endocrinol Lett
; 45(1): 76-80, 2024 Jan 31.
Article
em En
| MEDLINE
| ID: mdl-38295430
ABSTRACT
INTRODUCTION:
Recurrent Cushing's disease (recurrent CD) is an uncommon and intricate clinical form of Cushing's syndrome. However, the connection between the pathological types of ACTH-secreting PitNETs and the clinical signs of recurrent CD remains uncertain. CASE DESCRIPTION A 64-year-old woman, previously diagnosed with renal carcinoma, was admitted to our hospital due to recent weight gain. Previous endocrine tests indicated fluctuating hypercortisolemia and a recurrent pituitary tumor over the past six years. She underwent two transsphenoidal hypophysectomies, and histopathological analysis of the tumor revealed it as a densely granulated corticotroph tumor (DGCT), a subtype of TPIT-lineage PitNET, accompanied by tumor apoplexy.CONCLUSION:
This case highlights the connection between recurrent CD and the pathological subtypes of TPIT-lineage DGCT-PitNETs.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hipofisárias
/
Tumores Neuroendócrinos
/
Hipersecreção Hipofisária de ACTH
/
Neoplasias Renais
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article