Successful Treatment of Epstein-Barr Virus Reactivation-associated Transverse Myelitis Following Herpes Zoster with Intravenous Rituximab in a Cord Blood Transplant Recipient.
Intern Med
; 63(17): 2445-2450, 2024 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-38296479
ABSTRACT
The Epstein-Barr virus (EBV) is associated with many malignancies and autoimmune diseases, including multiple sclerosis. In addition, EBV rarely but occasionally causes central nervous system (CNS) complications. We herein report a case of transverse myelitis (TM) associated with systemic EBV reactivation after herpes zoster infection in a cord blood transplant recipient. Identification of EBV-infected peripheral blood cells revealed a predominance of B cells. Notably, intravenous rituximab ameliorated EBV reactivation and TM. Since the CNS infiltration rate of intravenous rituximab is markedly low, the clinical efficacy of rituximab against TM suggests that EBV reactivation may cause TM via immune-mediated mechanisms.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ativação Viral
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Herpesvirus Humano 4
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Infecções por Vírus Epstein-Barr
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Transplante de Células-Tronco de Sangue do Cordão Umbilical
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Rituximab
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Herpes Zoster
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Mielite Transversa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article