The Addis Ababa Lions: Whole-Genome Sequencing of a Rare and Precious Population.
Genome Biol Evol
; 16(2)2024 02 01.
Article
em En
| MEDLINE
| ID: mdl-38302110
ABSTRACT
Lions are widely known as charismatic predators that once roamed across the globe, but their populations have been greatly affected by environmental factors and human activities over the last 150â
yr. Of particular interest is the Addis Ababa lion population, which has been maintained in captivity at around 20 individuals for over 75â
yr, while many wild African lion populations have become extinct. In order to understand the molecular features of this unique population, we conducted a whole-genome sequencing study on 15 Addis Ababa lions and detected 4.5 million distinct genomic variants compared with the reference African lion genome. Using functional annotation, we identified several genes with mutations that potentially impact various traits such as mane color, body size, reproduction, gastrointestinal functions, cardiovascular processes, and sensory perception. These findings offer valuable insights into the genetics of this threatened lion population.
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2024
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Article