Sham surgery for the trialing of cell-based therapies to the CNS may not be necessary.
Cell Stem Cell
; 31(2): 158-160, 2024 02 01.
Article
em En
| MEDLINE
| ID: mdl-38306992
ABSTRACT
Sham surgery is often required for cell therapies adopting a randomized placebo-controlled double-blinded trial design. Using the case of dopamine neuron therapy for Parkinson's disease, we argue that alternative trial designs should be considered instead, for several reasons relating to ethics, patient burden, ease of unblinding, and cost.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Terapia Baseada em Transplante de Células e Tecidos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article