A novel multiscale framework for delineating cancer evolution from subclonal compositions.
J Theor Biol
; 582: 111743, 2024 04 07.
Article
em En
| MEDLINE
| ID: mdl-38307450
ABSTRACT
OBJECTIVE:
Owing to the heterogeneity in the evolution of cancer, distinguishing between diverse growth patterns and predicting long-term outcomes based on short-term measurements poses a great challenge.METHODS:
A novel multiscale framework is proposed to unravel the connections between the population dynamics of cancer growth (i.e., aggressive, bounded, and indolent) and the cellular-subclonal dynamics of cancer evolution. This framework employs the non-negative lasso (NN-LASSO) algorithm to forge a link between an ordinary differential equation (ODE)-based population model and a cellular evolution model.RESULTS:
The findings of our current work not only affirm the impact of subclonal composition on growth dynamics but also identify two significant subclones within heterogeneous growth patterns. Moreover, the subclonal compositions at the initial time are able to accurately discriminate diverse growth patterns through a machine learning algorithm.CONCLUSION:
The proposed multiscale framework successfully delineates the intricate landscape of cancer evolution, bridging the gap between long-term growth dynamics and short-term measurements, both in simulated and real-world data. This methodology provides a novel avenue for thorough exploration into the realm of cancer evolution.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article