ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation.
Cell Rep
; 43(2): 113720, 2024 Feb 27.
Article
em En
| MEDLINE
| ID: mdl-38308845
ABSTRACT
LMNA gene mutation can cause muscular dystrophy, and post-translational modification plays a critical role in regulating its function. Here, we identify that lamin A is palmitoylated at cysteine 522, 588, and 591 residues, which are reversely catalyzed by palmitoyltransferase zinc finger DHHC-type palmitoyltransferase 5 (ZDHHC5) and depalmitoylase α/ß hydrolase domain 7 (ABHD7). Furthermore, the metabolite lactate promotes palmitoylation of lamin A by inhibiting the interaction between it and ABHD7. Interestingly, low-level palmitoylation of lamin A promotes, whereas high-level palmitoylation of lamin A inhibits, murine myoblast differentiation. Together, these observations suggest that ABHD7-mediated depalmitoylation of lamin A controls myoblast differentiation.
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Base de dados:
MEDLINE
Assunto principal:
Lamina Tipo A
/
Distrofias Musculares
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article