A fluorogenic nitric oxide donor induced by yellow LED light for cells proliferation inhibition and imaging.
Nitric Oxide
; 145: 1-7, 2024 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-38309328
ABSTRACT
Nitric oxide (NO), as a vital cellular signalling molecule in physiological processes, has been found to play an important role in various biological functions. In this study, we rationally designed three NO donors by tethering nitrobenzene derivatives to three fluorescent chromophores. NX-NO was found to release NO and exhibit a high fluorescence turn-on signal ratio upon exposure to LED yellow light. Additionally, it had excellent photo-stability and good inhibitory activity against cancer cell proliferation, and was successfully applied to cell imaging. Moreover, we detected the release of NO and fluorescence response in the blood of a mouse, suggesting its potential therapeutic application in living organisms.
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1
Base de dados:
MEDLINE
Assunto principal:
Doadores de Óxido Nítrico
/
Corantes Fluorescentes
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article