Total Synthesis of Marine Polyketide Plakortone Q.
Chem Pharm Bull (Tokyo)
; 72(2): 179-185, 2024.
Article
em En
| MEDLINE
| ID: mdl-38311392
ABSTRACT
The total synthesis of the natural bicyclo[3.3.0]furanolactone polyketide, plakortone Q, was achieved in 24 steps from (R)-Roche ester. The main feature of this synthetic strategy is the stereoselective construction of a central tetrahydrofuran moiety with four consecutive stereoisomeric centers using the Upjohn dihydroxylation of oxiranyl-substituted alkenes and acid-mediated 5-endo-tet cyclization.
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MEDLINE
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Policetídeos
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En
Ano de publicação:
2024
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Article