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Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids.
Desai, Ridhdhi; Huang, Ling; Gonzalez, Raul S; Muthuswamy, Senthil K.
Afiliação
  • Desai R; Department of Medicine, Beth Israel Deaconess Medical Center, Cancer Research Institute, Harvard Medical School, Boston, Massachusetts.
  • Huang L; Department of Medicine, Beth Israel Deaconess Medical Center, Cancer Research Institute, Harvard Medical School, Boston, Massachusetts.
  • Gonzalez RS; Department of Medicine, Beth Israel Deaconess Medical Center, Cancer Research Institute, Harvard Medical School, Boston, Massachusetts.
  • Muthuswamy SK; Laboratory of Cancer Biology and Genetics, NCI, NIH, Bethesda, Maryland.
Mol Cancer Res ; 22(5): 440-451, 2024 May 02.
Article em En | MEDLINE | ID: mdl-38319286
ABSTRACT
IMPLICATIONS The study identifies an opportunity to discover a PKA-independent pathway downstream of oncogene GNAS for managing IPMN lesions and their progression to PDAC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Organoides / Cromograninas / Proteínas Quinases Dependentes de AMP Cíclico / Subunidades alfa Gs de Proteínas de Ligação ao GTP / Proliferação de Células Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Organoides / Cromograninas / Proteínas Quinases Dependentes de AMP Cíclico / Subunidades alfa Gs de Proteínas de Ligação ao GTP / Proliferação de Células Idioma: En Ano de publicação: 2024 Tipo de documento: Article