Augmenting regulatory T cells: new therapeutic strategy for rheumatoid arthritis.
Front Immunol
; 15: 1312919, 2024.
Article
em En
| MEDLINE
| ID: mdl-38322264
ABSTRACT
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune condition marked by inflammation of the joints, degradation of the articular cartilage, and bone resorption. Recent studies found the absolute and relative decreases in circulating regulatory T cells (Tregs) in RA patients. Tregs are a unique type of cells exhibiting immunosuppressive functions, known for expressing the Foxp3 gene. They are instrumental in maintaining immunological tolerance and preventing autoimmunity. Increasing the absolute number and/or enhancing the function of Tregs are effective strategies for treating RA. This article reviews the studies on the mechanisms and targeted therapies related to Tregs in RA, with a view to provide better ideas for the treatment of RA.
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1
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Linfócitos T Reguladores
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article