Prognostic impact of chronic obstructive pulmonary disease and bronchial asthma in patients with heart failure.
Rev Clin Esp (Barc)
; 224(3): 123-132, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38325624
ABSTRACT
PURPOSE:
To analyze the impact of chronic obstructive pulmonary disease (COPD) and bronchial asthma on therapeutic management and prognosis of patients with heart failure (HF).METHODS:
Analysis of the information collected in a clinical registry of patients referred to a specialized HF unit from January-2010 to June-2012. Clinical profile, treatment and prognosis of patients was evaluated, according to the presence of COPD or asthma. Survival analyses were conducted by means of Kaplan-Meier and Cox's methods. Median follow-up was 1493 days.RESULTS:
We studied 2577 patients, of which 251 (9.7%) presented COPD and 96 (3.7%) bronchial asthma. Significant differences among study groups were observed regarding to the prescription of beta-blockers (COPD=89.6%; asthma=87.5%; no bronchopathy=94.1%; p=0.002) and SGLT2 inhibitors (COPD=35.1%; asthma=50%; no bronchopathy=38.3%; p=0.036). Also, patients with bronchial disease received less frequently a defibrillator (COPD=20.3%; asthma=20.8%; no broncopathy=29%; p=0.004). COPD was independently associated with increased risk of all-cause mortality (HR=1.64; 95% CI 1.33-2.02), all-cause death or HF admission (HR=1.47; 95% CI 1.22-1.76) and cardiovascular death or heart transplantation (HR=1.39; 95% CI 1.08-1.79) as compared with patients with no bronchopathy. Bronchial asthma was not significantly associated with increased risk of adverse outcomes.CONCLUSIONS:
COPD, but not asthma, is an adverse independent prognostic factor in patients with HF.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Asma
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Doença Pulmonar Obstrutiva Crônica
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Insuficiência Cardíaca
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article