Copper-Catalyzed Selective Three-Component 1,2-Phosphonoazidation of 1,3-Dienes.
Org Lett
; 26(7): 1387-1392, 2024 Feb 23.
Article
em En
| MEDLINE
| ID: mdl-38341862
ABSTRACT
We report a copper-catalyzed selective 1,2-phosphonoazidation of conjugated dienes. This three-component reaction is achieved by using readily available P(O)-H compounds and bench-stable NaN3. Salient features of this strategy include its mild reaction conditions, broad functional group tolerance, and high chemoselectivity and regioselectivity. Moreover, the compatibility with the late-stage functionalization of drug molecules, the potential for scalable production, and the feasibility of further modifications of the products underscore the practical utility of this protocol in synthetic applications.
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MEDLINE
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En
Ano de publicação:
2024
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Article