Generation of an induced pluripotent stem cell line from patient with atrial fibrillation with KCNQ1 p.Ser209Pro mutation.
Stem Cell Res
; 76: 103336, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38341987
ABSTRACT
Gain-of-function mutations in the KCNQ1 gene can cause atrial fibrillation. In this study, we generated an induced stem cell line (GRCHJUi001) from one member of an atrial fibrillation family line, whom had heterozygous mutation in the KCNQ1 gene c.625 T > C (p.Ser209Pro), and the cell line showed maintenance of stem cells characterized by morphology, normal karyotype, and pluripotency.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
/
Células-Tronco Pluripotentes Induzidas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article