Bioinspired Injectable Polyurethane Underwater Adhesive with Fast Bonding and Hemostatic Properties.
Adv Sci (Weinh)
; 11(16): e2308538, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38350723
ABSTRACT
Underwater adhesives with injectable, organic solvent-free, strong, fast adhesion, and hemostatic properties have become an urgent need in biomedical field. Herein, a novel polyurethane underwater adhesive (PUWA) inspired by mussels is developed utilizing the rapid post-cure reaction of isocyanate esterification without organic solvents. The PUWA is created through the injectable two component curing process of component A (biocompatible polyurethane prepolymer) and component B (dopamine modified lysine derivatives chain extender-LDA and crosslinker-L3DA). The two-component adhesive cures quickly and firmly underwater, with an impressive bonding strength of 40 kPa on pork skin and excellent burst pressure of 394 mmHg. Moreover, the PUWA exhibits robust adhesion strength in hostile environments with acid, alkali and saline solutions. Combined with excellent biocompatibility and hemostatic performance, the PUWA demonstrates effectively sealing wounds and promoting healing. With the ability to bond diverse substrates rapidly and strongly, the PUWA holds significant potential for application in both biomedical and industrial fields.
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Base de dados:
MEDLINE
Assunto principal:
Poliuretanos
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Hemostáticos
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Adesivos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article