Serum free light chains among twin siblings: is the kappa/lambda ratio genetically determined?
Biomarkers
; 29(2): 100-104, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38353603
ABSTRACT
BACKGROUND:
Serum kappa, lambda, the K/λ light chain concentrations are used for screening, diagnosis, and monitoring of patients with multiple myeloma and other plasma cell disorders. Biological variation studies conducted on healthy subjects showed that free light chains have a low within and high between-individual variation. We determined if this variation were genetically linked.METHODS:
We obtained a single serum sample from 16 pairs of identical twins, 8 neonate twins, and 19 presumed directly-related siblings children, measured Κ and λ light chains and computed the Κ/λ ratio.RESULTS:
As expected, Κ/λ results from each twin neonate were near identical (reflecting maternal/placental transfer). For older children and adult twins, the Κ/λ ratio form a cluster of results that were a subset of the reference range. There was one outlier, a female with a high, different from her twin sister. She likely had a monoclonal gammopathy (no followup was possible). Excluding this pair, results from neonate twins (14.4% ±10.3%) and non-neonate twins (18.0 ± 15.3%) were not significantly different. Results between non-twin siblings were more scattered (53.2%±53.4%) and different from neonate and non-neonate twin adult and children.CONCLUSION:
We suggest that the Κ/λ free light chains may be genetically linked.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Gêmeos
/
Cadeias Leves de Imunoglobulina
/
Irmãos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article