Ir(iii)/Ag(i)-catalyzed directly C-H amidation of arenes with OH-free hydroxyamides as amidating agents.
RSC Adv
; 14(9): 5975-5980, 2024 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-38362076
ABSTRACT
A versatile Ir(iii)-catalyzed C-H amidation of arenes by employing readily available and stable OH-free hydroxyamides as a novel amidation source. The reaction occurred with high efficiency and tolerance of a range of functional groups. A wide scope of aryl OH-free hydroxyzamides, including conjugated and challenging non-conjugated OH-free hydroxyzamides, were capable of this transformation and no addition of an external oxidant is required. This protocol provided a simple, straightforward and economic method to a variety N-(2-(1H-pyrazol-1-yl)alkyl)amide derivates with good to excellent yield. Mechanistic study demonstrated that reversible C-H bond functionalisation might be involved in this reaction.
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MEDLINE
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Ano de publicação:
2024
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Article