An allosteric palindromic hairpin probe based dual-mode interactive strand displacement amplification enables robust miRNA biosensing.
Chem Commun (Camb)
; 60(21): 2910-2913, 2024 Mar 07.
Article
em En
| MEDLINE
| ID: mdl-38363200
ABSTRACT
This study introduces an allosteric palindromic hairpin probe (APHP)-based dual-mode interactive strand displacement amplification (DMI-SDA) system for ultrasensitive detection of microRNA-155. The system achieves exceptional signal amplification and improved signal preservation using dimeric G-triplexes as signal reporters, enabling robust detection of miRNA-155, representing a promising avenue in molecular diagnosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Técnicas Biossensoriais
/
MicroRNAs
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article