Prevalence and Predictive Factors for Celiac Disease in Children With Type 1 Diabetes: Whom and When to Screen? A Nationwide Longitudinal Cohort Study of Swedish Children.
Diabetes Care
; 47(4): 756-760, 2024 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-38363973
ABSTRACT
OBJECTIVE:
To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines. RESEARCH DESIGN ANDMETHODS:
The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes Diagnosis study in Sweden.RESULTS:
The prevalence of biopsy-proven CD was 9.8%, of which 58.2% already had a CD diagnosis before or at T1D onset. Almost all, 95.9%, were diagnosed with CD within 5 years after the T1D diagnosis. Younger age at the T1D diagnosis and being homozygote for DQ2 increased the risk of CD after T1D, but neither sex nor diabetes-related autoantibodies were associated with the risk.CONCLUSIONS:
Age at and time after diabetes diagnosis should be considered in screening guidelines for CD in children with T1D.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença Celíaca
/
Diabetes Mellitus Tipo 1
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article