Haemolytic transfusion reactions caused by non-ABO red cell antibodies reported to the Norwegian Haemovigilance System 2004-2020.
Vox Sang
; 119(5): 483-489, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38373854
ABSTRACT
BACKGROUND AND OBJECTIVES:
The aim of this study was to analyse the reports received in the Norwegian Haemovigilance System from 2004 to 2020 on acute and delayed haemolytic transfusion reactions caused by non-ABO red cell antibodies. MATERIALS ANDMETHODS:
Antibody specificity, clinical symptoms and outcomes were included when available.RESULTS:
After transfusion of 3.7 million red cell concentrates, reports on 78 cases of haemolytic transfusion reactions caused by non-ABO red cell antibodies were received, corresponding to an incidence of 1 in 47,000 transfused red cell concentrates. There were 30 acute and 48 delayed haemolytic transfusion reactions. A total of 113 red cell antibodies were found 82 alloantibodies, 6 autoantibodies and 25 cases where the antibody specificity could not be determined. Two fatalities occurred one caused by anti-Wra and one caused by an unidentified red cell antibody. The most frequently reported antibody specificities were those in the Rh and Kidd blood group systems, representing 24% and 14%, respectively, of all the antibodies identified. In six cases, errors occurred, leading to the issuing of blood units without the required phenotype match.CONCLUSIONS:
Despite the possible underreporting, the low number of serious haemolytic transfusion reactions reflects an adequate pre-transfusion practice by the Norwegian blood banks.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Reação Transfusional
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Isoanticorpos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article