Human cytokeratin 1 plays a role in the interaction of Pteropine orthoreovirus with Hek293 cells but not HeLa cells.
Microbes Infect
; 26(1-2): 105243, 2024.
Article
em En
| MEDLINE
| ID: mdl-38380604
ABSTRACT
Pteropine orthoreovirus (PRV) causes respiratory tract infections in humans. Despite its emergence as a zoonotic and respiratory virus, little is known about its cell tropism, which hampers progress in fully understanding its pathogenesis in humans. Hek293 cells are most susceptible to PRV infection, while HeLa cells are the least. Human cytokeratin 1 (CK1) was identified as the protein that interacts with PRV. The immunofluorescence assay and qPCR results revealed prior treatment with anti-CK1 may provide Hek293 cells protection against PRV. The KRT1-knockout Hek293 cells were less susceptible to PRV infection. Further study into the pathogenesis of PRV in humans is needed.
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Base de dados:
MEDLINE
Assunto principal:
Orthoreovirus
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Infecções por Reoviridae
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Doenças dos Peixes
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article