Utilizing the International Normalized Ratio-Platelet Index for Predicting Hospital Outcomes After Spontaneous Supratentorial Intracerebral Hemorrhage.
World Neurosurg
; 185: e555-e562, 2024 05.
Article
em En
| MEDLINE
| ID: mdl-38382762
ABSTRACT
OBJECTIVE:
Spontaneous intracerebral hemorrhage (ICH) poses a public health issue due to its elevated mortality rates. The International Normalized Ratio-platelet index (INR-Plt index) has recently been recognized as a predictive factor for liver disease progression. The potential of applying the INR-Plt index in forecasting ICH prognosis presents an intriguing subject. This study endeavors to examine the correlation between the INR-Plt index and hospital outcomes in patients with spontaneous supratentorial ICH.METHODS:
A retrospective examination of 283 adult ICH patients was undertaken. The INR-Plt index was computed using the formula [INR/platelet counts (1000/µL)] × 100. The clinical outcomes evaluated consisted of mortality rates and the Modified Rankin Scale (mRS) at discharge. An unfavorable outcome was defined as an mRS score from 4 to 6.RESULTS:
The study found a significant correlation between the INR-Plt index and hospital mortality (odds ratio 4.31, 95% CI 1.07-17.31, P = 0.04). There was a 43% rise in mortality risk for every 0.1 unit increase in the INR-Plt index. Kaplan-Meier survival curves illustrated a considerably lower survival rate at discharge for patients with an INR-Plt index >0.8 (log-rank test P = 0.047). Regarding unfavorable outcomes, the INR-Plt index was not a significant factor according to logistic regression analyses.CONCLUSIONS:
The INR-Plt index is a predictor of hospital mortality in patients with spontaneous supratentorial ICH. A higher INR-Plt index value is associated with an increased risk of mortality, underlining the potential usefulness of this composite index in guiding clinical decision-making and enabling risk stratification.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hemorragia Cerebral
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Mortalidade Hospitalar
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Coeficiente Internacional Normatizado
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article