[Research Progress of NK Cell Therapy in Multiple Myeloma Treatment --Review].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 32(1): 297-301, 2024 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-38387938
ABSTRACT
Multiple myeloma (MM) is a hematologic neoplasm characterized by malignant proliferation of monoclonal plasma cells in the bone marrow. NK cells, a class of innate lymphocytes with potent natural killer activity, are capable of recognizing and destroying tumor cells and virally infected cells, and have attracted attention as a potential anticancer therapy. In patients with MM, NK cells are suppressed in number and function, resulting in reduced immune surveillance and clearance of myeloma cells. Restoring or enhancing the killing effect of NK cells on myeloma cells is an important strategy for MM immunotherapy, and some progress has been made in clinical trials targeting NK cellîrelated therapies. This article reviews the research progress on the applications prospects of NK cell in MM immunotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Mieloma Múltiplo
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article