Advancements in the Research of GEF-H1: Biological Functions and Tumor Associations.
Curr Mol Pharmacol
; 17: e18761429274883, 2024.
Article
em En
| MEDLINE
| ID: mdl-38389417
ABSTRACT
Guanine nucleotide exchange factor H1 (GEF-H1) is a unique protein modulated by the GDP/GTP exchange. As a regulator of the Rho-GTPase family, GEF-H1 can be activated through a microtubule-depended mechanism and phosphorylation regulation, enabling it to perform various pivotal biological functions across multiple cellular activities. These include the regulation of Rho-GTPase, cytoskeleton formation, cellular barrier, cell cycle, mitosis, cell differentiation, and vesicle trafficking. Recent studies have revealed its crucial effect on the tumor microenvironment (TME) components, promoting tumor initiation and progress. Consequently, an in-depth exploration of GEF-H1's biological roles and association with tumors holds promise for its potential as a valuable molecular target in tumor treatment.
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Base de dados:
MEDLINE
Assunto principal:
Proteína rhoA de Ligação ao GTP
/
Neoplasias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article