Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets.
Cell Mol Neurobiol
; 44(1): 25, 2024 Feb 23.
Article
em En
| MEDLINE
| ID: mdl-38393376
ABSTRACT
Ferroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to ferroptosis. The mechanisms of ferroptosis were summarized into three interrelated aspects iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What's more, the causal relationship between ferroptosis and IS has been elucidated by several processes. The disruption of the blood-brain barrier, the release of excitatory amino acids, and the inflammatory response after ischemic stroke all lead to the disorder of iron metabolism and the antioxidant system. Based on these statements, we reviewed the reported effects of compounds and drugs treating IS by modulating key molecules in ferroptosis. Through detailed analysis of the roles of these key molecules, we have also more clearly demonstrated the essential effect of ferroptosis in the occurrence of IS so as to provide new targets and ideas for the therapeutic targets of IS.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ferroptose
/
AVC Isquêmico
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article