Electroencephalographic slowing during REM sleep in older adults with subjective cognitive impairment and mild cognitive impairment.
Sleep
; 47(6)2024 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-38394454
ABSTRACT
STUDY OBJECTIVES:
In older adults with Alzheimer's disease, slowing of electroencephalographic (EEG) activity during REM sleep has been observed. Few studies have examined EEG slowing during REM in those with mild cognitive impairment (MCI) and none have examined its relationship with cognition in this at-risk population.METHODS:
Two hundred and ten older adults (mean ageâ =â 67.0, SDâ =â 8.2 years) underwent comprehensive neuropsychological, medical, and psychiatric assessment and overnight polysomnography. Participants were classified as subjective cognitive impairment (SCI; nâ =â 75), non-amnestic MCI (naMCI, nâ =â 85), and amnestic MCI (aMCI, nâ =â 50). REM EEG slowing was defined as (δâ +â θ)/(αâ +â σâ +â ß) power and calculated for frontal, central, parietal, and occipital regions. Analysis of variance compared REM EEG slowing between groups. Correlations between REM EEG slowing and cognition, including learning and memory, visuospatial and executive functions, were examined within each subgroup.RESULTS:
The aMCI group had significantly greater REM EEG slowing in the parietal and occipital regions compared to the naMCI and SCI groups (partial η2â =â 0.06, pâ <â 0.05 and 0.06, pâ <â 0.05, respectively), and greater EEG slowing in the central region compared to SCI group (partial η2â =â 0.03, pâ <â 0.05). Greater REM EEG slowing in parietal (râ =â -0.49) and occipital regions (râ =â -0.38 [O1/M2] and -0.33 [O2/M1]) were associated with poorer visuospatial performance in naMCI.CONCLUSIONS:
REM EEG slowing may differentiate older adults with memory impairment from those without. Longitudinal studies are now warranted to examine the prognostic utility of REM EEG slowing for cognitive and dementia trajectories.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sono REM
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Polissonografia
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Eletroencefalografia
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Disfunção Cognitiva
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article