Fluid retention and weight loss in refractory cancer cachexia.

Amano, Koji; Okamura, Satomi; Baracos, Vickie; Mori, Naoharu; Sakaguchi, Tatsuma; Uneno, Yu; Hiratsuka, Yusuke; Hamano, Jun; Miura, Tomofumi; Ishiki, Hiroto; Yokomichi, Naosuke; Hatano, Yutaka; Morita, Tatsuya; Mori, Masanori

Amano, Koji; Okamura, Satomi; Baracos, Vickie; Mori, Naoharu; Sakaguchi, Tatsuma; Uneno, Yu; Hiratsuka, Yusuke; Hamano, Jun; Miura, Tomofumi; Ishiki, Hiroto; Yokomichi, Naosuke; Hatano, Yutaka; Morita, Tatsuya; Mori, Masanori.

Afiliação

Amano K; Palliative and Supportive Care Center, Osaka University Hospital, Suita, Japan kojiamano4813@gmail.com.
Okamura S; Department of Psycho-Oncology and Palliative Medicine, Osaka International Cancer Institute, Osaka, Japan.
Baracos V; Department of Medical Innovation, Osaka University Hospital, Suita, Japan.
Mori N; Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.
Sakaguchi T; Department of Palliative and Supportive Medicine, Aichi Medical University, Nagakute, Japan.
Uneno Y; Department of Palliative and Supportive Medicine, Aichi Medical University, Nagakute, Japan.
Hiratsuka Y; Department of Therapeutic Oncology, Kyoto University, Kyoto, Japan.
Hamano J; Department of Palliative Medicine, Tohoku University School of Medicine, Sendai, Japan.
Miura T; Department of Palliative and Supportive Care, University of Tsukuba, Tsukuba, Japan.
Ishiki H; Department of Palliative Medicine, National Cancer Center-Hospital East, Kashiwa, Japan.
Yokomichi N; Department of Palliative Medicine, National Cancer Center Hospital, Tokyo, Japan.
Hatano Y; Department of Palliative and Supportive Care, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
Morita T; Department of Palliative Care, Daini Kyoritsu Hospital, Kawanishi, Japan.
Mori M; Department of Palliative and Supportive Care, Seirei Mikatahara General Hospital, Hamamatsu, Japan.

BMJ Support Palliat Care ; 2024 Feb 23.

Article em En | MEDLINE | ID: mdl-38395597

ABSTRACT

ABSTRACT

OBJECTIVES:

It is unknown to what extent the fluid retention (FR) status disrupts the detection of weight loss rate (WLR) in adult patients with advanced cancer. This study aimed to determine the association of FR status with WLR.

METHODS:

This study was a secondary analysis of a prospective cohort study. FR was evaluated as follows oedema (0, no; 1, yes), pleural effusion (0, no; 1, yes but asymptomatic; 2, symptomatic) and ascites (0, no; 1, yes but asymptomatic; 2, symptomatic). Patients were divided into three groups according to their FR scores no-FR (0), moderate-FR (1-2) and high-FR (3-5). Multiple regression analysis was performed.

RESULTS:

Four hundred and twenty patients were categorised no-FR group (n=164), moderate-FR group (n=158) and high-FR group (n=98). The prevalence of oedema, pleural effusion and ascites was 63.9%, 27.8% and 36.7% in the moderate-FR group, and 93.9%, 61.3% and 82.6% in high-FR group. The means of WLR were 9.2, 8.4 and 3.8 in the groups. The high-FR group and the FR score of 5 were correlated with WLR (estimate -4.71, 95% CI -7.84 to -1.58; estimate -10.29, 95% CI -17.84 to -2.74).