Protein Translation in the Pathogenesis of Parkinson's Disease.
Int J Mol Sci
; 25(4)2024 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-38397070
ABSTRACT
In recent years, research into Parkinson's disease and similar neurodegenerative disorders has increasingly suggested that these conditions are synonymous with failures in proteostasis. However, the spotlight of this research has remained firmly focused on the tail end of proteostasis, primarily aggregation, misfolding, and degradation, with protein translation being comparatively overlooked. Now, there is an increasing body of evidence supporting a potential role for translation in the pathogenesis of PD, and its dysregulation is already established in other similar neurodegenerative conditions. In this paper, we consider how altered protein translation fits into the broader picture of PD pathogenesis, working hand in hand to compound the stress placed on neurons, until this becomes irrecoverable. We will also consider molecular players of interest, recent evidence that suggests that aggregates may directly influence translation in PD progression, and the implications for the role of protein translation in our development of clinically useful diagnostics and therapeutics.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article