Development and Internal Validation of a Model for Predicting Overall Survival in Subjects with MAFLD: A Cohort Study.
J Clin Med
; 13(4)2024 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-38398493
ABSTRACT
Background & Aims:
Fatty liver disease with metabolic dysfunction (MAFLD) is a new concept proposed to replace the previous concept of Non-Alcoholic Hepatic Steatosis (NAFLD). We developed and internally validated a prognostic model to predict the likelihood of death in a cohort of subjects with MAFLD.Methods:
Our work involved twosteps:
the first was the construction of a bootstrapped multivariable Cox model for mortality risk prognosis and the second was its validation.Results:
The study cohort included 1506 subjects, of which 907 were used for internal validation. Discriminant measures for the final model were R2D 0.6845 and Harrell's C 0.8422 in the development and R2D 0.6930 and Harrell's C 0.8465 in the validation. We used the nine independent prognostic factors selected by the LASSO Cox procedure and fitted by the bootstrap Cox survival model, and observed ß were Gender 0.356 1.42 (p < 0.008), Age 0.146 (p < 0.001), Glycemia 0.004 (p < 0.002), Total Cholesterol -0.0040 (p < 0.009), Gamma Glutamyl Transpeptidase 0.009 (p < 0.001), SBP 0.009 (p < 0.036), DBP -0.016 (p < 0.041), ALP 0.008 (p < 0.071) and Widowhood 0.550 (p < 0.001).Conclusions:
We produced and validated a model to estimate the probability of death in subjects with MAFLD. The instruments we used showed satisfactory predictive capabilities.
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MEDLINE
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En
Ano de publicação:
2024
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Article