Study on the anti-cancer activity of α-phenethylamine ferrocenecarboxylic acid co-crystals.
Chirality
; 36(3): e23653, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38403899
ABSTRACT
Ferrocene derivatives show a wide range of pharmacological activities in the medical field, especially in the anti-tumor field, and can be used as candidate drugs or lead compounds for the treatment of tumors and other diseases. And α-phenethylamine is an important intermediate for the preparation of fine chemical products. (R)-(+)-1-Phenethylamine ferrocenecarboxylic acid/(S)-(-)-1-phenethylamine ferrocenecarboxylic acid were prepared, named compounds 1 and 2, respectively. Single crystal X-ray diffraction showed that compounds 1 and 2 crystallized in the orthorhombic system space group P21 21 21 , and the crystal structures of compounds 1 and 2 exhibited mirror symmetry. The inhibitory effect of two compounds on SW480, MDA-MB-231, and H1299 cells was tested by MTT colorimetry. The IC50 values of the compounds against cancer cells were also calculated. The anti-cancer effect was more pronounced for compounds in the S-configuration. Compound 2 made the wild-type cancer cells undergo apoptosis, thus preventing cancer; it also had the function of helping the cell gene repair defects.
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Base de dados:
MEDLINE
Assunto principal:
Fenetilaminas
/
Compostos Ferrosos
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Antineoplásicos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article