Decreased immune response in undernourished rats after air pollution exposure.
Environ Toxicol Pharmacol
; 107: 104400, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38408716
ABSTRACT
Children are highly vulnerable subpopulation to malnutrition and air pollution. We investigate, in a rat nutritional growth retardation (NGR) model, the impact of Residual Oil Fly Ash (ROFA) on the lung immune response using in vitro and ex vivo methods. In vitro Alveolar macrophages (AM) were isolated from Control (C) and NGR animals, cultured and treated with ROFA (1-100⯵g/ml) for 24â¯h. Ex vivo C and NGR rats were intranasally instilled with ROFA (1â¯mg/kg BW) or PBS. 24â¯h post-exposure AM were isolated and cultured. ROFA-treatment increased superoxide anion production and TNFα secretion in C-AM in vitro, though for NGR-AM this response was lower. A similar pattern was observed for TNFα and IL-6 secretion in ex vivo experiments. Regarding the antioxidant response, although NGR-AM showed increased Nrf2, after ROFA instillation an attenuated activation was observed. To conclude, chronic undernutrition altered AM response to ROFA affecting immune responsiveness to air pollutants.
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Base de dados:
MEDLINE
Assunto principal:
Desnutrição
/
Poluentes Atmosféricos
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Poluição do Ar
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article